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Pub - Dopamine and Learning / Pub - Learning and Motivation / Publications 2021-04-29
READ MOREIn: Learning & Memory PMID: 33723029 DOI: 10.1101/lm.053082.120 Abstract: The dopamine system has been implicated in decision-making particularly when associated with effortful behavior. We examined acute optogenetic stimulation of dopamine cells in the ventral tegmental area (VTA) as mice engaged in an effort-based decision-making task. Tyrosine hydroxylase-Cre mice were injected with Cre-dependent ChR2 or eYFP control […]
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News / Pub - Dopamine and Learning / Pub - Neuropsychiatric Illness / Publications 2019-05-31
READ MOREIn: Schizophrenia Bulletin PMID: 31150554 DOI: 10.1093/schbul/sbz043 Abstract: Impairments in reality testing are core features of numerous neuropsychiatric conditions. However, relatively few animal models have been developed to assess this critical facet of neuropsychiatric illness, thus impeding our understanding of the underlying central systems and circuits. Using mice in which dominant-negative Disrupted-in-Schizophrenia-1 is expressed throughout […]
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In: Behavioural Brain Research PMID: 27984049 DOI: 10.1016/j.bbr.2016.10.043 Abstract: Dopamine is known to influence motivational processes, however the precise role of this neurotransmitter remains a contentious issue. In the current study we sought to further characterize dopamine signaling in reward-based decision-making and consummatory behavior in mice, via lateral ventricle infusion of the dopamine D2 receptor […]